AUTHOR=Slaughter John , Sites Jeremy , Ballard Hubert , Bauer John , Schadler Aric , Severyn Nicholas 

TITLE=Comparison of the oxygenation index and the oxygen saturation index as clinical indicators for neonatal ECMO

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1586985

DOI=10.3389/fped.2025.1586985

ISSN=2296-2360

ABSTRACT=IntroductionNeonatal hypoxic respiratory failure is commonly assessed with the oxygenation index (OI) to determine severity and guide ECMO initiation. Calculation of the OI requires arterial blood sampling which can be difficult to obtain. A non-invasive alternative, the oxygen saturation index (OSI), has shown promise, but its utility in ECMO determination is not well-described. We aimed to evaluate the correlation between the OI and OSI in neonates requiring ECMO.MethodsWe pursued a retrospective chart review of 64 neonatal ECMO patients at Kentucky Children's Hospital (2012–2022) and analyzed OI and OSI values in the 12 h preceding ECMO initiation.ResultsA moderate correlation was observed between the OI and OSI. An OSI >17.41 predicted ECMO initiation, and OI can be estimated with the equation: OI = 1.978(OSI)—6.743.ConclusionThese findings suggest OSI may be a useful adjunct to OI for assessing neonatal respiratory failure and could be beneficial when arterial sampling is impractical.