As technology advances, more infants and young children are receiving general anesthesia for surgery, therapeutic procedures, or clinical examinations at a young age. However, whether general anesthetics can impact the function and structure of the developing brain remains an important, difficult, and contentious question. In clinic surgery, general anesthetics (GA) such as propofol, ketamine, nitrous oxide, isoflurane, sevoflurane, desflurane, and others have been commonly utilized. Human cohort studies show that the developing brains of young children are especially vulnerable to these anesthetics, which may induce neuronal damage and increase the likelihood of future learning and memory issues.
The current Research Topic intends to encompass fresh, rigorous, and promising research on anesthetic-induced neurotoxicity and neurocognitive impairment, addressing the age-dependent effects of anesthetics on developing brains and the underlying processes. In addition, we intend to gather pre-clinical and clinical data in order to give a joint commentary on techniques to guide clinical anesthetic and enhance neurocognitive protection in young children.
Pre-clinical and clinical research on anesthetic-induced neurotoxicity and neurocognitive impairment in developing brains are encouraged. Animal models, regular laboratory procedures, neuroimaging, psychophysiology, genetics, real-world research, longitudinal and multi-center designs, and other approaches may be used to answer these concerns. Brief Research Report, Correction, Data Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Review, Study Protocol, and Systematic Review are all acceptable article formats. This Research Topic may include, but is not limited to:
• Molecular mechanism of anesthetic-induced neurotoxicity
• Causal effects of anesthetics on perioperative neurocognitive problems
• Molecular, circuit, and network mechanisms of neurocognitive impairment
• Neurocognitive impairment biomarkers, correlations, and predictions
• Adjuvant medication effects on cognitive function under anesthesia
• Clinical implications for anesthetic practice and cognitive protection
As technology advances, more infants and young children are receiving general anesthesia for surgery, therapeutic procedures, or clinical examinations at a young age. However, whether general anesthetics can impact the function and structure of the developing brain remains an important, difficult, and contentious question. In clinic surgery, general anesthetics (GA) such as propofol, ketamine, nitrous oxide, isoflurane, sevoflurane, desflurane, and others have been commonly utilized. Human cohort studies show that the developing brains of young children are especially vulnerable to these anesthetics, which may induce neuronal damage and increase the likelihood of future learning and memory issues.
The current Research Topic intends to encompass fresh, rigorous, and promising research on anesthetic-induced neurotoxicity and neurocognitive impairment, addressing the age-dependent effects of anesthetics on developing brains and the underlying processes. In addition, we intend to gather pre-clinical and clinical data in order to give a joint commentary on techniques to guide clinical anesthetic and enhance neurocognitive protection in young children.
Pre-clinical and clinical research on anesthetic-induced neurotoxicity and neurocognitive impairment in developing brains are encouraged. Animal models, regular laboratory procedures, neuroimaging, psychophysiology, genetics, real-world research, longitudinal and multi-center designs, and other approaches may be used to answer these concerns. Brief Research Report, Correction, Data Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Review, Study Protocol, and Systematic Review are all acceptable article formats. This Research Topic may include, but is not limited to:
• Molecular mechanism of anesthetic-induced neurotoxicity
• Causal effects of anesthetics on perioperative neurocognitive problems
• Molecular, circuit, and network mechanisms of neurocognitive impairment
• Neurocognitive impairment biomarkers, correlations, and predictions
• Adjuvant medication effects on cognitive function under anesthesia
• Clinical implications for anesthetic practice and cognitive protection
